9 selections by the Buffalo Sabres in the 2025 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2025 | 9 | 1 | Buffalo Sabres | Radim Mrtka | D | Seattle | WHL | CZE |
| 2025 | 71 | 3 | Buffalo Sabres | David Bedkowski | D | Owen Sound | OHL | CAN |
| 2025 | 103 | 4 | Buffalo Sabres | Matous Kucharcik | C | Slavia Jr. | CZECHIA-JR. | ITA |
| 2025 | 116 | 4 | Buffalo Sabres | Samuel Meloche | G | Rouyn-Noranda | QMJHL | CAN |
| 2025 | 135 | 5 | Buffalo Sabres | Noah Laberge | D | Acadie-Bathurst | QMJHL | CAN |
| 2025 | 167 | 6 | Buffalo Sabres | Ashton Schultz | C | Chicago | USHL | USA |
| 2025 | 195 | 7 | Buffalo Sabres | Melvin Novotny | LW | Leksand Jr. | SWEDEN-JR. | SWE |
| 2025 | 199 | 7 | Buffalo Sabres | Yevgeni Prokhorov | G | Dinamo-Shinnik Jr. | RUSSIA-JR. | BLR |
| 2025 | 219 | 7 | Buffalo Sabres | Ryan Rucinski | C | Youngstown | USHL | USA |