11 selections by the Buffalo Sabres in the 2022 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2022 | 9 | 1 | Buffalo Sabres | Matt Savoie | C | Winnipeg | WHL | CAN |
| 2022 | 16 | 1 | Buffalo Sabres | Noah Ostlund | C | Djurgarden Jr. | SWEDEN-JR. | SWE |
| 2022 | 28 | 1 | Buffalo Sabres | Jiri Kulich | C | Karlovy Vary | CZREP | CZE |
| 2022 | 41 | 2 | Buffalo Sabres | Topias Leinonen | G | JYP Jr. | FINLAND-JR. | FIN |
| 2022 | 74 | 3 | Buffalo Sabres | Viktor Neuchev | LW | Yekaterinburg 2 | RUSSIA-JR. | RUS |
| 2022 | 106 | 4 | Buffalo Sabres | Mats Lindgren | D | Kamloops | WHL | CAN |
| 2022 | 134 | 5 | Buffalo Sabres | Vsevolod Komarov | D | Quebec | QMJHL | RUS |
| 2022 | 170 | 6 | Buffalo Sabres | Jake Richard | RW | Muskegon | USHL | USA |
| 2022 | 187 | 6 | Buffalo Sabres | Gustav Karlsson | C | Orebro Jr. | SWEDEN-JR. | SWE |
| 2022 | 202 | 7 | Buffalo Sabres | Joel Ratkovic Berndtsson | RW | Frolunda Jr. | SWEDEN-JR. | SWE |
| 2022 | 211 | 7 | Buffalo Sabres | Linus Sjodin | C | Rogle | SWEDEN | SWE |