8 selections by the Buffalo Sabres in the 2000 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2000 | 15 | 1 | Buffalo Sabres | Artem Kriukov | C | Yaroslavl 2 | RUSSIA-3 | RUS |
| 2000 | 48 | 2 | Buffalo Sabres | Gerard Dicaire | D | Seattle | WHL | MKD |
| 2000 | 111 | 4 | Buffalo Sabres | Ghyslain Rousseau | G | Baie Comeau | QMJHL | CAN |
| 2000 | 149 | 5 | Buffalo Sabres | Denis Denisov | LW | HC Moscow | RUS | RUS |
| 2000 | 213 | 7 | Buffalo Sabres | Vasily Bizyayev | LW | CSKA Jr. | Russia | RUS |
| 2000 | 220 | 7 | Buffalo Sabres | Paul Gaustad | F | Portland | WHL | USA |
| 2000 | 258 | 8 | Buffalo Sabres | Sean McMorrow | D | Kitchener | OHL | CAN |
| 2000 | 277 | 9 | Buffalo Sabres | Ryan Courtney | LW | Windsor | OHL | CAN |