6 selections by the Buffalo Sabres in the 2015 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2015 | 2 | 1 | Buffalo Sabres | Jack Eichel | C | Boston University | H-EAST | USA |
| 2015 | 51 | 2 | Buffalo Sabres | Brendan Guhle | D | Prince Albert | WHL | CAN |
| 2015 | 92 | 4 | Buffalo Sabres | Will Borgen | D | Moorhead | HIGH-MN | USA |
| 2015 | 122 | 5 | Buffalo Sabres | Devante Stephens | D | Kelowna | WHL | CAN |
| 2015 | 152 | 6 | Buffalo Sabres | Giorgio Estephan | C | Lethbridge | WHL | CAN |
| 2015 | 182 | 7 | Buffalo Sabres | Ivan Chukarov | D | Minnesota Wilderness | NAHL | USA |