8 selections by the Buffalo Sabres in the 2008 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2008 | 12 | 1 | Buffalo Sabres | Tyler Myers | D | Kelowna | WHL | USA |
| 2008 | 26 | 1 | Buffalo Sabres | Tyler Ennis | C | Medicine Hat | WHL | CAN |
| 2008 | 44 | 2 | Buffalo Sabres | Luke Adam | C | St. John's | QMJHL | CAN |
| 2008 | 81 | 3 | Buffalo Sabres | Corey Fienhage | D | Eastview High | HIGH-MN | USA |
| 2008 | 101 | 4 | Buffalo Sabres | Justin Jokinen | RW | Cloquet | HIGH-MN | USA |
| 2008 | 104 | 4 | Buffalo Sabres | Jordon Southorn | D | PEI | QMJHL | CAN |
| 2008 | 134 | 5 | Buffalo Sabres | Jacob Lagace | LW | Chicoutimi | QMJHL | CAN |
| 2008 | 164 | 6 | Buffalo Sabres | Nick Crawford | D | Saginaw | OHL | CAN |