6 selections by the Buffalo Sabres in the 2006 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2006 | 24 | 1 | Buffalo Sabres | Dennis Persson | D | Vasteras | SWEDEN | SWE |
| 2006 | 46 | 2 | Buffalo Sabres | Jhonas Enroth | G | Sodertalje | SWEDEN | SWE |
| 2006 | 57 | 2 | Buffalo Sabres | Mike Weber | D | Windsor | OHL | USA |
| 2006 | 117 | 4 | Buffalo Sabres | Felix Schutz | C | Saint John | QMJHL | DEU |
| 2006 | 147 | 5 | Buffalo Sabres | Alex Biega | D | Salisbury | USHSE | CAN |
| 2006 | 207 | 7 | Buffalo Sabres | Benjamin Breault | C | Baie Comeau | QMJHL | CAN |