9 selections by the Buffalo Sabres in the 2005 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2005 | 13 | 1 | Buffalo Sabres | Marek Zagrapan | C | Chicoutimi | QMJHL | SVK |
| 2005 | 48 | 2 | Buffalo Sabres | Philip Gogulla | F | Koln | GERMANY | DEU |
| 2005 | 87 | 3 | Buffalo Sabres | Marc-Andre Gragnani | D | P.E.I. | QMJHL | CAN |
| 2005 | 96 | 4 | Buffalo Sabres | Chris Butler | D | Sioux City | USHL | USA |
| 2005 | 142 | 5 | Buffalo Sabres | Nathan Gerbe | C | USA U-18 | USA | USA |
| 2005 | 182 | 6 | Buffalo Sabres | Adam Dennis | G | London | OHL | CAN |
| 2005 | 191 | 6 | Buffalo Sabres | Vjateslav Buravchikov | D | Krylja | RUSSIA-2 | RUS |
| 2005 | 208 | 7 | Buffalo Sabres | Matt Generous | D | N.E. Jr. Falcons | EJHL | USA |
| 2005 | 227 | 7 | Buffalo Sabres | Andrew Orpik | D | Thayer Academy | USHSE | USA |