10 selections by the Buffalo Sabres in the 2016 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2016 | 8 | 1 | Buffalo Sabres | Alex Nylander | LW | Mississauga | OHL | CAN |
| 2016 | 33 | 2 | Buffalo Sabres | Rasmus Asplund | C | Farjestad | SWEDEN | SWE |
| 2016 | 69 | 3 | Buffalo Sabres | Cliff Pu | RW | London | OHL | CAN |
| 2016 | 86 | 3 | Buffalo Sabres | Casey Fitzgerald | D | Boston College | H-EAST | USA |
| 2016 | 99 | 4 | Buffalo Sabres | Brett Murray | LW | Carleton Place | CCHL | CAN |
| 2016 | 129 | 5 | Buffalo Sabres | Philip Nyberg | D | Linkoping Jr. | SWEDEN-JR. | SWE |
| 2016 | 130 | 5 | Buffalo Sabres | Vojtech Budik | D | Prince Albert | WHL | CZE |
| 2016 | 159 | 6 | Buffalo Sabres | Brandon Hagel | LW | Red Deer | WHL | CAN |
| 2016 | 189 | 7 | Buffalo Sabres | Austin Osmanski | D | Mississauga | OHL | USA |
| 2016 | 190 | 7 | Buffalo Sabres | Vasily Glotov | C | Lvy St. Petersburg 2 | RUSSIA-JR. | RUS |