9 selections by the Buffalo Sabres in the 2010 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2010 | 23 | 1 | Buffalo Sabres | Mark Pysyk | D | Edmonton | WHL | CAN |
| 2010 | 68 | 3 | Buffalo Sabres | Jerome Leduc | D | Rouyn-Noranda | QMJHL | CAN |
| 2010 | 75 | 3 | Buffalo Sabres | Kevin Sundher | C | Chilliwack | WHL | CAN |
| 2010 | 83 | 3 | Buffalo Sabres | Matt MacKenzie | D | Calgary | WHL | CAN |
| 2010 | 98 | 4 | Buffalo Sabres | Steven Shipley | C | Owen Sound | OHL | CAN |
| 2010 | 143 | 5 | Buffalo Sabres | Gregg Sutch | RW | Mississauga | OHL | CAN |
| 2010 | 173 | 6 | Buffalo Sabres | Cedrick Henley | LW | Val d'Or | QMJHL | CAN |
| 2010 | 203 | 7 | Buffalo Sabres | Christian Isackson | RW | St. Thomas | HIGH-MN | USA |
| 2010 | 208 | 7 | Buffalo Sabres | Riley Boychuk | LW | Portland | WHL | CAN |