11 selections by the Buffalo Sabres in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 1 | 1 | Buffalo Sabres | Owen Power | D | Michigan | BIG10 | CAN |
| 2021 | 14 | 1 | Buffalo Sabres | Isak Rosen | RW | Leksand | SWEDEN | SWE |
| 2021 | 33 | 2 | Buffalo Sabres | Prokhor Poltapov | LW | CSKA 2 | RUSSIA-JR. | RUS |
| 2021 | 53 | 2 | Buffalo Sabres | Aleksandr Kisakov | LW | Dynamo Moscow 2 | RUSSIA-JR. | RUS |
| 2021 | 88 | 3 | Buffalo Sabres | Stiven Sardarian | RW | CSKA 2 | RUSSIA-JR. | RUS |
| 2021 | 95 | 3 | Buffalo Sabres | Josh Bloom | LW | Saginaw | OHL | CAN |
| 2021 | 97 | 4 | Buffalo Sabres | Olivier Nadeau | RW | Shawinigan | QMJHL | CAN |
| 2021 | 159 | 5 | Buffalo Sabres | Viljami Marjala | LW | Quebec | QMJHL | FIN |
| 2021 | 161 | 6 | Buffalo Sabres | William Von Barnekow Lofberg | C | Malmo Jr. | SWEDEN-JR. | SWE |
| 2021 | 188 | 6 | Buffalo Sabres | Nikita Novikov | D | Dynamo Moscow 2 | RUSSIA-JR. | RUS |
| 2021 | 193 | 7 | Buffalo Sabres | Tyson Kozak | C | Portland | WHL | CAN |