13 selections by the Pittsburgh Penguins in the 2025 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2025 | 11 | 1 | Pittsburgh Penguins | Benjamin Kindel | C | Calgary | WHL | CAN |
| 2025 | 22 | 1 | Pittsburgh Penguins | Bill Zonnon | RW | Rouyn-Noranda | QMJHL | CAN |
| 2025 | 24 | 1 | Pittsburgh Penguins | William Horcoff | C | Michigan | BIG10 | CAN |
| 2025 | 39 | 2 | Pittsburgh Penguins | Peyton Kettles | D | Swift Current | WHL | CAN |
| 2025 | 73 | 3 | Pittsburgh Penguins | Charlton Trethewey | D | USA U-18 | NTDP - USHL | USA |
| 2025 | 84 | 3 | Pittsburgh Penguins | Gabriel D'Aigle | G | Victoriaville | QMJHL | CAN |
| 2025 | 91 | 3 | Pittsburgh Penguins | Brady Peddle | D | Waterloo | USHL | CAN |
| 2025 | 105 | 4 | Pittsburgh Penguins | Travis Hayes | RW | Sault Ste. Marie | OHL | USA |
| 2025 | 130 | 5 | Pittsburgh Penguins | Ryan Miller | C | Portland | WHL | CAN |
| 2025 | 148 | 5 | Pittsburgh Penguins | Quinn Beauchesne | D | Guelph | OHL | CAN |
| 2025 | 154 | 5 | Pittsburgh Penguins | Jordan Charron | RW | Sault Ste. Marie | OHL | CAN |
| 2025 | 169 | 6 | Pittsburgh Penguins | Carter Sanderson | LW | Muskegon | USHL | USA |
| 2025 | 201 | 7 | Pittsburgh Penguins | Kale Dach | C | Sherwood Park | BCHL | CAN |