5 selections by the Pittsburgh Penguins in the 2006 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2006 | 2 | 1 | Pittsburgh Penguins | Jordan Staal | C | Peterborough | OHL | CAN |
| 2006 | 32 | 2 | Pittsburgh Penguins | Carl Sneep | D | Brainerd H.S. | USHSW | USA |
| 2006 | 65 | 3 | Pittsburgh Penguins | Brian Strait | D | USA U-18 | USA | USA |
| 2006 | 125 | 5 | Pittsburgh Penguins | Chad Johnson | G | Alaska-Fairbanks | CCHA | CAN |
| 2006 | 185 | 7 | Pittsburgh Penguins | Timo Seppanen | D | IFK | FINLAND | FIN |