5 selections by the Pittsburgh Penguins in the 2022 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2022 | 21 | 1 | Pittsburgh Penguins | Owen Pickering | D | Swift Current | WHL | CAN |
| 2022 | 118 | 4 | Pittsburgh Penguins | Sergei Murashov | G | LOKO-76 Yaroslavl | RUSSIA-JR. | RUS |
| 2022 | 150 | 5 | Pittsburgh Penguins | Zam Plante | C | Hermantown | HIGH-MN | DEU |
| 2022 | 167 | 6 | Pittsburgh Penguins | Nolan Collins | D | Sudbury | OHL | CAN |
| 2022 | 182 | 6 | Pittsburgh Penguins | Luke Devlin | C | St. Andrew's College | HIGH-ON | USA |