10 selections by the Pittsburgh Penguins in the 2000 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2000 | 18 | 1 | Pittsburgh Penguins | Brooks Orpik | D | Boston College | H-EAST | USA |
| 2000 | 52 | 2 | Pittsburgh Penguins | Shane Endicott | C | Seattle | WHL | CAN |
| 2000 | 84 | 3 | Pittsburgh Penguins | Peter Hamerlik | G | Skalica | — | SVK |
| 2000 | 124 | 4 | Pittsburgh Penguins | Michel Ouellet | RW | Rimouski | QMJHL | CAN |
| 2000 | 146 | 5 | Pittsburgh Penguins | David Koci | D | Sparta Praha Jr. | — | CZE |
| 2000 | 185 | 6 | Pittsburgh Penguins | Patrick Foley | LW | U. of New Hampshire | NCAA | USA |
| 2000 | 216 | 7 | Pittsburgh Penguins | Jim Abbott | LW | U. of New Hampshire | NCAA | USA |
| 2000 | 248 | 8 | Pittsburgh Penguins | Steven Crampton | RW | Moose Jaw | WHL | CAN |
| 2000 | 273 | 9 | Pittsburgh Penguins | Roman Simicek | C | HPK Hameenlinna | FINLAND | CZE |
| 2000 | 280 | 9 | Pittsburgh Penguins | Nick Boucher | G | Dartmouth College | ECAC | CAN |