6 selections by the Pittsburgh Penguins in the 2010 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2010 | 20 | 1 | Pittsburgh Penguins | Beau Bennett | RW | Penticton | BCHL | USA |
| 2010 | 80 | 3 | Pittsburgh Penguins | Bryan Rust | RW | USA U-18 | USHL | USA |
| 2010 | 110 | 4 | Pittsburgh Penguins | Tom Kuhnhackl | RW | Landshut Cann. | GERMAN-2 | DEU |
| 2010 | 140 | 5 | Pittsburgh Penguins | Kenny Agostino | LW | Delbarton | HIGH-NJ | USA |
| 2010 | 152 | 6 | Pittsburgh Penguins | Joe Rogalski | D | Sarnia | OHL | USA |
| 2010 | 170 | 6 | Pittsburgh Penguins | Reid McNeill | D | London | OHL | CAN |