7 selections by the Pittsburgh Penguins in the 2005 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2005 | 1 | 1 | Pittsburgh Penguins | Sidney Crosby | C | Rimouski | QMJHL | CAN |
| 2005 | 61 | 2 | Pittsburgh Penguins | Michael Gergen | F | Shattuck-St. Mary's | USHSW | USA |
| 2005 | 62 | 3 | Pittsburgh Penguins | Kris Letang | D | Val d'Or | QMJHL | CAN |
| 2005 | 125 | 4 | Pittsburgh Penguins | Tommi Leinonen | D | Karpat Jr. | Finland Jr. | FIN |
| 2005 | 126 | 5 | Pittsburgh Penguins | Tim Crowder | RW | South Surrey | BCHL | CAN |
| 2005 | 194 | 6 | Pittsburgh Penguins | Jean-Philippe Paquet | D | Shawinigan | QMJHL | CAN |
| 2005 | 195 | 7 | Pittsburgh Penguins | Joe Vitale | C | Sioux Falls | USHL | USA |