5 selections by the Pittsburgh Penguins in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 58 | 2 | Pittsburgh Penguins | Tristan Broz | C | Fargo | USHL | USA |
| 2021 | 154 | 5 | Pittsburgh Penguins | Isaac Belliveau | D | Gatineau | QMJHL | CAN |
| 2021 | 194 | 7 | Pittsburgh Penguins | Ryan McCleary | D | Portland | WHL | CAN |
| 2021 | 215 | 7 | Pittsburgh Penguins | Daniel Laatsch | D | Sioux City | USHL | USA |
| 2021 | 218 | 7 | Pittsburgh Penguins | Kirill Tankov | C | SKA-Varyagi | RUSSIA-JR. | RUS |