6 selections by the Ottawa Senators in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 10 | 1 | Ottawa Senators | Tyler Boucher | RW | USA U-18 | NTDP | USA |
| 2021 | 39 | 2 | Ottawa Senators | Zack Ostapchuk | C | Vancouver | WHL | CAN |
| 2021 | 49 | 2 | Ottawa Senators | Ben Roger | D | London | OHL | CAN |
| 2021 | 74 | 3 | Ottawa Senators | Oliver Johansson | LW | Timra | SWEDEN-2 | SWE |
| 2021 | 123 | 4 | Ottawa Senators | Carson Latimer | RW | Edmonton | WHL | CAN |
| 2021 | 202 | 7 | Ottawa Senators | Chandler Romeo | D | Brantford | GOJHL | CAN |