3 selections by the Toronto Maple Leafs in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 57 | 2 | Toronto Maple Leafs | Matthew Knies | LW | Tri-City | USHL | USA |
| 2021 | 153 | 5 | Toronto Maple Leafs | Ty Voit | LW | Sarnia | OHL | USA |
| 2021 | 185 | 6 | Toronto Maple Leafs | Vyacheslav Peksa | G | Irbis Kazan | RUSSIA-JR. | RUS |