10 selections by the Toronto Maple Leafs in the 2000 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2000 | 24 | 1 | Toronto Maple Leafs | Brad Boyes | C | Erie | OHL | CAN |
| 2000 | 51 | 2 | Toronto Maple Leafs | Kris Vernarsky | C | Plymouth | OHL | USA |
| 2000 | 70 | 3 | Toronto Maple Leafs | Mikael Tellqvist | G | Djurgarden | SWEDEN | SWE |
| 2000 | 90 | 3 | Toronto Maple Leafs | Jean-Francois Racine | G | Drummondville | QMJHL | CAN |
| 2000 | 100 | 4 | Toronto Maple Leafs | Miguel Delisle | RW | Ottawa | OHL | CAN |
| 2000 | 179 | 6 | Toronto Maple Leafs | Vadim Sozinov | C | Novokuznetsk 2 | RUSSIA-JR. | KAZ |
| 2000 | 209 | 7 | Toronto Maple Leafs | Markus Seikola | D | TPS Jr. | FINLAND | FIN |
| 2000 | 223 | 7 | Toronto Maple Leafs | Lubos Velebny | D | Zvolen Jr. | Slovakia | SVK |
| 2000 | 254 | 8 | Toronto Maple Leafs | Alexander Shinkar | RW | Cherepovets | RUS | RUS |
| 2000 | 265 | 9 | Toronto Maple Leafs | Jean-Philippe Cote | D | Cape Breton | QMJHL | CAN |