11 selections by the Toronto Maple Leafs in the 2016 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2016 | 1 | 1 | Toronto Maple Leafs | Auston Matthews | C | Zurich | SWISS | USA |
| 2016 | 31 | 2 | Toronto Maple Leafs | Egor Korshkov | RW | Yaroslavl | RUSSIA | RUS |
| 2016 | 57 | 2 | Toronto Maple Leafs | Carl Grundstrom | RW | Modo | SWEDEN | SWE |
| 2016 | 62 | 3 | Toronto Maple Leafs | Joseph Woll | G | USA U-18 | USHL | USA |
| 2016 | 72 | 3 | Toronto Maple Leafs | James Greenway | D | USA U-18 | USHL | USA |
| 2016 | 92 | 4 | Toronto Maple Leafs | Adam Brooks | C | Regina | WHL | CAN |
| 2016 | 101 | 4 | Toronto Maple Leafs | Keaton Middleton | D | Saginaw | OHL | CAN |
| 2016 | 122 | 5 | Toronto Maple Leafs | Vladimir Bobylev | RW | Victoria | WHL | RUS |
| 2016 | 152 | 6 | Toronto Maple Leafs | Jonathan Walker | D | Victoria | WHL | USA |
| 2016 | 179 | 6 | Toronto Maple Leafs | Nicolas Mattinen | D | London | OHL | CAN |
| 2016 | 182 | 7 | Toronto Maple Leafs | Nikolai Chebykin | LW | Mvd Balashikha 2 | RUSSIA | RUS |