4 selections by the St. Louis Blues in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 17 | 1 | St. Louis Blues | Zack Bolduc | C | Rimouski | QMJHL | CAN |
| 2021 | 71 | 3 | St. Louis Blues | Simon Robertsson | RW | Skelleftea | SWEDEN | SWE |
| 2021 | 145 | 5 | St. Louis Blues | Tyson Galloway | D | Calgary | WHL | CAN |
| 2021 | 198 | 7 | St. Louis Blues | Ivan Vorobyov | RW | Khanty-Mansiysk 2 | RUSSIA-JR. | RUS |