9 selections by the San Jose Sharks in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 7 | 1 | San Jose Sharks | William Eklund | LW | Djurgarden | SWEDEN | SWE |
| 2021 | 81 | 3 | San Jose Sharks | Benjamin Gaudreau | G | Sarnia | OHL | CAN |
| 2021 | 103 | 4 | San Jose Sharks | Gannon Laroque | D | Victoria | WHL | CAN |
| 2021 | 121 | 4 | San Jose Sharks | Ethan Cardwell | RW | Barrie | OHL | CAN |
| 2021 | 135 | 5 | San Jose Sharks | Artem Guryev | D | Lindsay | OJHL | RUS |
| 2021 | 156 | 5 | San Jose Sharks | Max McCue | C | London | OHL | CAN |
| 2021 | 167 | 6 | San Jose Sharks | Liam Gilmartin | LW | USA U-18 | NTDP | DEU |
| 2021 | 177 | 6 | San Jose Sharks | Theo Jacobsson | C | Modo Jr. | SWEDEN-JR. | SWE |
| 2021 | 199 | 7 | San Jose Sharks | Evgenii Kashnikov | D | Gatineau | QMJHL | RUS |