6 selections by the Philadelphia Flyers in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 46 | 2 | Philadelphia Flyers | Samu Tuomaala | RW | Karpat Jr. | FINLAND-JR. | FIN |
| 2021 | 78 | 3 | Philadelphia Flyers | Aleksei Kolosov | G | Minsk | RUSSIA | BLR |
| 2021 | 110 | 4 | Philadelphia Flyers | Brian Zanetti | D | Lugano Jr. | SWISS-JR. | CHE |
| 2021 | 158 | 5 | Philadelphia Flyers | Ty Murchison | D | USA U-18 | NTDP | USA |
| 2021 | 174 | 6 | Philadelphia Flyers | Ethan Samson | D | Prince George | WHL | CAN |
| 2021 | 206 | 7 | Philadelphia Flyers | Owen McLaughlin | C | Mount St. Charles | HIGH-RI | USA |