9 selections by the Columbus Blue Jackets in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 5 | 1 | Columbus Blue Jackets | Kent Johnson | C | Michigan | BIG10 | CAN |
| 2021 | 12 | 1 | Columbus Blue Jackets | Cole Sillinger | C | Sioux Falls | USHL | USA |
| 2021 | 25 | 1 | Columbus Blue Jackets | Corson Ceulemans | D | Brooks | AJHL | CAN |
| 2021 | 69 | 3 | Columbus Blue Jackets | Stanislav Svozil | D | Brno | CZREP | CZE |
| 2021 | 101 | 4 | Columbus Blue Jackets | Guillaume Richard | D | Tri-City | USHL | CAN |
| 2021 | 132 | 5 | Columbus Blue Jackets | Nikolai Makarov | D | CSKA 2 | RUSSIA-JR. | RUS |
| 2021 | 133 | 5 | Columbus Blue Jackets | James Malatesta | LW | Quebec | QMJHL | CAN |
| 2021 | 165 | 6 | Columbus Blue Jackets | Ben Boyd | LW | Charlottetown | QMJHL | CAN |
| 2021 | 197 | 7 | Columbus Blue Jackets | Martin Rysavy | RW | Prerov | CZREP-2 | CZE |