4 selections by the Colorado Avalanche in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 28 | 1 | Colorado Avalanche | Oskar Olausson | RW | HV 71 | SWEDEN | SWE |
| 2021 | 61 | 2 | Colorado Avalanche | Sean Behrens | D | USA U-18 | NTDP | USA |
| 2021 | 92 | 3 | Colorado Avalanche | Andrei Buyalsky | C | Dubuque | USHL | KAZ |
| 2021 | 220 | 7 | Colorado Avalanche | Taylor Makar | LW | Brooks | AJHL | CAN |