8 selections by the Colorado Avalanche in the 2010 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2010 | 17 | 1 | Colorado Avalanche | Joey Hishon | C | Owen Sound | OHL | CAN |
| 2010 | 49 | 2 | Colorado Avalanche | Calvin Pickard | G | Seattle | WHL | CAN |
| 2010 | 71 | 3 | Colorado Avalanche | Michael Bournival | LW | Shawinigan | QMJHL | CAN |
| 2010 | 95 | 4 | Colorado Avalanche | Stephen Silas | D | Belleville | OHL | CAN |
| 2010 | 107 | 4 | Colorado Avalanche | Sami Aittokallio | G | Ilves Jr. | Finland Jr. | FIN |
| 2010 | 137 | 5 | Colorado Avalanche | Troy Rutkowski | D | Portland | WHL | CAN |
| 2010 | 139 | 5 | Colorado Avalanche | Luke Walker | RW | Portland | WHL | USA |
| 2010 | 197 | 7 | Colorado Avalanche | Luke Moffatt | C | USA U-18 | USHL | USA |