8 selections by the Detroit Red Wings in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 6 | 1 | Detroit Red Wings | Simon Edvinsson | D | Frolunda Jr. | SWEDEN-JR. | SWE |
| 2021 | 15 | 1 | Detroit Red Wings | Sebastian Cossa | G | Edmonton | WHL | CAN |
| 2021 | 36 | 2 | Detroit Red Wings | Shai Buium | D | Sioux City | USHL | USA |
| 2021 | 70 | 3 | Detroit Red Wings | Carter Mazur | LW | Tri-City | USHL | USA |
| 2021 | 114 | 4 | Detroit Red Wings | Redmond Savage | C | USA U-18 | NTDP | USA |
| 2021 | 134 | 5 | Detroit Red Wings | Liam Dower Nilsson | C | Frolunda Jr. | SWEDEN-JR. | SWE |
| 2021 | 155 | 5 | Detroit Red Wings | Oscar Plandowski | D | Charlottetown | QMJHL | CAN |
| 2021 | 166 | 6 | Detroit Red Wings | Pasquale Zito | LW | Windsor | OHL | CAN |