10 selections by the Arizona Coyotes in the 2021 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 2021 | 9 | 1 | Arizona Coyotes | Dylan Guenther | RW | Edmonton | WHL | CAN |
| 2021 | 11 | 1 | Arizona Coyotes | — | — | — | — | — |
| 2021 | 37 | 2 | Arizona Coyotes | Josh Doan | RW | Chicago | USHL | USA |
| 2021 | 43 | 2 | Arizona Coyotes | Ilya Fedotov | LW | Nizhny Novgorod 2 | RUSSIA-JR. | RUS |
| 2021 | 60 | 2 | Arizona Coyotes | J.J. Moser | D | Biel | SWISS | CHE |
| 2021 | 107 | 4 | Arizona Coyotes | Emil Lilleberg | D | Sarpsborg | NORWAY | NOR |
| 2021 | 122 | 4 | Arizona Coyotes | Rasmus Korhonen | G | Assat Jr. | FINLAND-JR. | FIN |
| 2021 | 139 | 5 | Arizona Coyotes | Manix Landry | C | Gatineau | QMJHL | USA |
| 2021 | 171 | 6 | Arizona Coyotes | Cal Thomas | D | Maple Grove | HIGH-MN | USA |
| 2021 | 223 | 7 | Arizona Coyotes | Sam Lipkin | LW | Chicago | USHL | USA |