Buffalo Sabres 1999 Draft Picks12 selections by the Buffalo Sabres in the 1999 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 1999 | 20 | 1 | Buffalo Sabres | Barrett Heisten | LW | U. of Maine | NCAA | USA |
| 1999 | 35 | 2 | Buffalo Sabres | Milan Bartovic | RW | — | Slovakia | SVK |
| 1999 | 55 | 2 | Buffalo Sabres | Doug Janik | D | U. of Maine | NCAA | USA |
| 1999 | 64 | 2 | Buffalo Sabres | Mike Zigomanis | C | Kingston Frontenacs | OHL | CAN |
| 1999 | 73 | 3 | Buffalo Sabres | Tim Preston | LW | Seattle Thunderbirds | WHL | CAN |
| 1999 | 117 | 4 | Buffalo Sabres | Karel Mosovsky | LW | Regina Pats | WHL | CZE |
| 1999 | 138 | 5 | Buffalo Sabres | Ryan Miller | G | Soo Indians | NAHL | USA |
| 1999 | 146 | 5 | Buffalo Sabres | Matthew Kinch | D | Calgary Hitmen | WHL | CAN |
| 1999 | 178 | 6 | Buffalo Sabres | Seneque Hyacinthe | LW | Val-d'Or Foreurs | QMJHL | CAN |
| 1999 | 206 | 7 | Buffalo Sabres | Bret Dececco | RW | Seattle Thunderbirds | WHL | CAN |
| 1999 | 235 | 8 | Buffalo Sabres | Brad Self | C | Peterborough Petes | OHL | CAN |
| 1999 | 263 | 9 | Buffalo Sabres | Craig Brunel | RW | Prince Albert Raiders | WHL | CAN |