Buffalo Sabres 1981 Draft Picks12 selections by the Buffalo Sabres in the 1981 NHL Entry Draft.
| Year | Pick | Round | Team | Player | Pos | Amateur Club | League | Country |
|---|---|---|---|---|---|---|---|---|
| 1981 | 17 | 1 | Buffalo Sabres | Jiri Dudacek | RW | Kladno | Czechoslovakia | CZE |
| 1981 | 38 | 2 | Buffalo Sabres | Hannu Virta | D | TPS Turku | FINLAND | FIN |
| 1981 | 59 | 3 | Buffalo Sabres | James Aldred | LW | Kingston Canadians | OHL | CAN |
| 1981 | 60 | 3 | Buffalo Sabres | Colin Chisholm | D | Calgary Wranglers | WHL | CAN |
| 1981 | 80 | 4 | Buffalo Sabres | Jeff Eatough | RW | Cornwall Royals | QMJHL | CAN |
| 1981 | 83 | 4 | Buffalo Sabres | Anders Wikberg | LW | Timra Jrs. | Sweden | SWE |
| 1981 | 101 | 5 | Buffalo Sabres | Mauri Eivola | C | TPS Turku | FINLAND | FIN |
| 1981 | 122 | 6 | Buffalo Sabres | Ali Butorac | D | Ottawa 67's | OHL | CAN |
| 1981 | 143 | 7 | Buffalo Sabres | Heikki Leime | D | TPS Turku | FINLAND | FIN |
| 1981 | 164 | 8 | Buffalo Sabres | Gaetano Orlando | C | Providence College | NCAA | CAN |
| 1981 | 185 | 9 | Buffalo Sabres | Venci Sebek | D | Niagara Falls Flyers | OHL | USA |
| 1981 | 206 | 10 | Buffalo Sabres | Warren Harper | LW | Prince Albert Saints | SJHL | CAN |